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Health » Ketoconazole Shampoo: How to Use It Correctly for Dandruff and Dermatitis?

Ketoconazole Shampoo: How to Use It Correctly for Dandruff and Dermatitis?

Do you have Ketoconazole gel and don't know how to apply it? We'll explain how many times a week it should be applied, how long it should be left on, and when you'll see the first results.

by Wendy Lazcano
October 6, 2025
Reading time: 2 mins read
A woman with brown hair sits, listening attentively to a dark-skinned female doctor in a white coat, who is talking animatedly in front of a table with a laptop, in a modern office with beige walls and a circular mirror on the wall.

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Wendy Lazcano
Editor at Vitals Today
She is an experienced journalist who has worked in print media such as Diario de Cuba and Review Energy, as well as hosting radio (Wradio/Grupo PRISA) and television (Canal 33) programs. A specialist in politics and regulations, Wendy stands out for her ability to analyze and explain complex issues.
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If you have intense dandruff or dermatitis seborrheic, the ketoconazole 2% It is a first-line treatment. The approved regimen is simple: twice weekly for 2–4 weeks, waiting 3–5 minutes before rinsing. If there is a response, progress to maintenance once weekly or every 1–2 weeks to prevent relapse.

Key fact: Official information in Spain does not specify a timeframe for improvement of "1–2 weeks"; it suggests consulting a doctor if there is no improvement after 4 weeks.

How many times a week should I use it at first?

Start with two weekly applications spaced 2–4 weeks apart. This is the recommended dosage form. Some historical sources describe two to three doses per week in studies, but three doses per week are not listed as an approved dosage form; only consider it if your doctor recommends it.

Once the itching and scaling are under control, continue with maintenance: once a week or every 1–2 weeks, adjusting according to symptoms and season (it tends to get worse in winter).

How long should you let it sit before rinsing?

Wet your scalp. Apply a small amount and massage into the scaly areas. Leave on for 3–5 minutes for the antifungal to take effect, then rinse thoroughly with water.

Avoid contact with your eyes and don't rub vigorously or use very hot water. If you also have flaking on your eyebrows or nose, follow the instructions given to you by your healthcare professional.

When will I start to see results?

Many people notice improvement around two weeks, according to Nizoral's product title, but this isn't an official AEMPS (Spanish Medical Association) timeframe. The important thing is to assess the response: if you don't improve within four weeks, consult to confirm the diagnosis (psoriasis, ringworm, contact dermatitis) or add topical anti-inflammatory drugs.

Safe use and possible side effects: dryness, mild stinging, temporary hair changes, or local irritation. Do not apply to broken skin. During pregnancy and breastfeeding, skin absorption is minimal, but confirm the guidelines with your healthcare professional.

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