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Health » What is Mupirocin and what skin infections is it used for?

What is Mupirocin and what skin infections is it used for?

Mupirocin is a key antibiotic ointment for skin infections. We explain what it's used for, whether it's effective on spots or wounds, and whether you need a prescription in Spain.

by Wendy Lazcano
September 25, 2025
Reading time: 2 mins read
A dark-haired doctor, wearing a white coat and a stethoscope around his neck, is having an animated conversation with a patient in a modern doctor's office setting, with a computer and illuminated windows in the background.

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Wendy Lazcano
Editor at Vitals Today
She is an experienced journalist who has worked in print media such as Diario de Cuba and Review Energy, as well as hosting radio (Wradio/Grupo PRISA) and television (Canal 33) programs. A specialist in politics and regulations, Wendy stands out for her ability to analyze and explain complex issues.
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When a wound appears that oozes, a pimple becomes inflamed, or a yellowish scab appears, we look for something that will act quickly. Mupirocin It is an antibiotic ointment for cutaneous use that is applied locally to stop bacteria in superficial infections.

It is primarily prescribed for impetigo, folliculitis, superinfected wounds or eczema, and around infected nails (paronychia). It is not effective against fungi or viruses.

How does Mupirocin work against bacteria?

It blocks bacterial protein synthesis by inhibiting isoleucyl-tRNA synthase. This prevents the growth of Staphylococcus aureus (including many strains resistant to other antibiotics) and Streptococcus pyogenes, the main cause of impetigo and many skin infections. It is used in 2% ointment, applying a thin layer 2–3 times a day for 5–10 days. Before applying the ointment, wash the area with soap and water, dry gently, and then apply the ointment.

Avoid eyes and mouth; do not use inside the nose except in specific formulations. If there is no improvement within 3–5 days, consult a doctor. Common adverse effects: burning, itching, redness, or local dryness; allergic reactions are rare. If pregnant or breastfeeding, seek medical advice.

After applying the ointment, the area may be covered with an occlusive dressing or gauze if necessary, unless otherwise directed by a doctor. Do not use it on large areas, major burns, or as a preventative "just in case."

Does it work for wounds, infected pimples or boils?

Yes, when there is a superficial bacterial superinfection. In wounds and erosions, it reduces the bacterial load and aids healing if infection is suspected. In the case of infected pimples or folliculitis, it controls the localized infection; it is not a treatment for common acne without infection.

For boils, it may help if they are small and superficial; if there is severe pain, fever, rapid spread, or a large abscess, evaluation for drainage and, sometimes, oral antibiotics is required.

Do you need a prescription at a pharmacy in Spain?

Yes. In Spain, mupirocin 2% is available by prescription. This ensures correct use, limits resistance, and prevents unnecessary infections from being treated with antibiotics. If you suspect a skin infection, consult your doctor or pharmacist to confirm the diagnosis and receive the appropriate treatment. Responsible use today, effective tomorrow.

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