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Health » Mupirocin vs. Fucidin: Which is Better for Skin Infections?

Mupirocin vs. Fucidin: Which is Better for Skin Infections?

by Wendy Lazcano
September 29, 2025
Reading time: 2 mins read
A man sitting opposite a doctor wearing a white coat and stethoscope in an office with a table, a tablet, and several medication bottles visible. The doctor appears to be explaining something to the patient.

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Wendy Lazcano
Editor at Vitals Today
She is an experienced journalist who has worked in print media such as Diario de Cuba and Review Energy, as well as hosting radio (Wradio/Grupo PRISA) and television (Canal 33) programs. A specialist in politics and regulations, Wendy stands out for her ability to analyze and explain complex issues.
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When a mild skin infection (impetigo, folliculitis, superinfected dermatitis) occurs, many patients ask: Mupirocin vs FucidineWhich does the doctor prefer and why? The answer usually depends on the type of injury, its location, and your medical history. Here's the lowdown, based on official data sheets.

What are they for?

Both are topical antibiotics. Mupirocin 2% is indicated for limited superficial skin infections caused by susceptible organisms, such as impetigo or folliculitis. Fusidic acid 2% (Fucidine/Fusidín)) It is used for impetigo and impetiginous dermatosis; in extensive forms it is combined with systemic antibiotics.

How are they applied?

Generally, 2–3 times a day for 5–10 days. With mupirocin, if there is no improvement after 5 days, the diagnosis is reconsidered; do not exceed 10 days. With Fucidine, 7–10 days; the cream works best on macerated folds or lesions.

Key precautions?

Avoid eyes and mucous membranes with both. Mupirocin ointment contains macrogols (PEG): large wounds or reduced kidney function may be absorbed; use with caution and follow medical supervision.

So... which one does the doctor choose? If the lesion is in folds or macerated, Fucidine cream is usually preferred. For localized impetigo or folliculitis in dry areas, mupirocin ointment is a common choice. In extensive cases or with systemic signs, topical treatment is not enough: evaluation and possible oral antibiotics are necessary.

AspectMupirocin 2%Fusidic acid 2% (Fucidine)
IndicationsImpetigo, folliculitis, limited skin superinfectionsImpetigo/impetiginizing dermatitis; localized; combine if extensive
Posology23 applications/day; review 5 days; max. 10 days23 applications/day during 7–10 days
ShapeOintmentCream (useful in folds/maceration)
PrecautionsPEG: caution in large wounds/IRAvoid eyes/mucous membranes; clean before applying.

Practical message: Start early, apply the correct dose, and return to the doctor if you don't improve within 5–7 days or if the lesions spread. For more detailed questions about Mupirocin vs. Fucidin, your doctor will evaluate the location, extent, and your medical history.

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