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If you get a mild skin infection (impetigo, folliculitis, infected dermatitis), a common question is: Mupirocin vs Fucidine, which does a doctor choose and why? The choice typically hinges on the lesion type, where it is, and your health background.
What are Mupirocin and Fucidin used for?
Both are topical antibiotics. Mupirocin 2% is indicated for limited superficial skin infections caused by susceptible organisms, such as impetigo or folliculitis. Fusidic acid 2% (Fucidine/Fusidin)) It is used in impetigo and impetiginized dermatosis; in extensive forms it is combined with systemic antibiotics.
How are they applied?
Generally, it is applied 2 or 3 times a day for about 5 to 10 days. With mupirocin, if there is no improvement after 5 days, the diagnosis should be reconsidered, and the total treatment duration should not exceed 10 days. With Fucidin, use is usually maintained for 7 to 10 days, and the cream works best on skin folds or macerated lesions.
Key precautions?
Avoid contact with eyes and mucous membranes with both. Mupirocin ointment contains macrogols (PEG). In large wounds or in patients with reduced kidney function, it may be absorbed, so it is recommended to use it with caution and under medical supervision.
So, which one does the doctor choose? If the lesion is in skin folds or there is maceration, Fucidin cream is often a particularly helpful option. For localized impetigo or folliculitis in dry areas, mupirocin ointment usually works well.
In extensive cases or those with systemic symptoms, topical treatment is not enough. In these situations, medical evaluation is necessary, and your doctor may prescribe an oral antibiotic.
| Aspect | Mupirocin 2% | Fusidic acid 2% (Fucidine) |
|---|---|---|
| Indications | Impetigo, folliculitis, limited skin superinfections | Impetigo/impetiginizing dermatitis; localized; combine if extensive |
| Posology | 23 applications/day; review 5 days; max. 10 days | 23 applications/day during 7–10 days |
| Shape | Ointment | Cream (useful in folds/maceration) |
| Precautions | PEG: caution in large wounds/IR | Avoid eyes/mucous membranes; clean before applying. |
It is best to start treatment as soon as possible, respect the indicated dose, and request a new medical evaluation if you do not notice improvement in a few days or if the lesions increase.
To decide between Mupirocin and Fucidin, your doctor will assess the affected area, how far the infection has spread, and your medical history. Always follow the instructions of your doctor and pharmacist. This information is for informational purposes only and does not replace an individual medical evaluation.
