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Motilium (domperidone) is used to relieve nausea and vomiting in adults and adolescents aged 12 years and older who weigh at least 35 kg. It is not an antacid, it does not protect the stomach lining, and it will not treat the underlying cause if the problem is an infection, poisoning, or gastroenteritis that needs a different treatment plan.
Is it taken before or after eating?
Motilium is recommended before meals. If you take it afterward, it may take longer to be absorbed and for the effect to be felt, so it is usually preferable to take it before meals.
The general recommendation is to use the lowest dose that works for you and for the shortest possible time. It is not recommended to extend the treatment beyond 7 days without consulting a doctor.
| Presentation | Usual dose | Maximum per day | Approximate duration |
|---|---|---|---|
| 10 mg tablets | 1 tablet up to 3 times a day | 30 mg | Up to 7 days without consultation |
| Oral suspension 1 mg/ml | 10 ml up to 3 times a day | 30 ml | Up to 7 days without consultation |
Can Motilium and alcohol be mixed?
It's best not to. Alcohol can worsen nausea and make you more prone to dehydration, and it can also impair your ability to assess effects like drowsiness or palpitations. If you've been drinking and experience an irregular heartbeat, shortness of breath, or fainting, stop taking Motilium and seek medical attention.
Can Motilium be combined with other medications?
Some medications can be combined, but there are clear exceptions. A very common question is whether Motilium and Buscapina or Motilium and paracetamol can be taken on the same day. According to official information for Motilium, paracetamol and Buscapina are not listed among the medications with which their use is discouraged or contraindicated.
The main warning is to avoid combinations that increase the risk of heart rhythm disturbances, especially with drugs that prolong the QT interval or with potent CYP3A4 inhibitors, including some antibiotics and antifungals. If you are taking other medications, check with your pharmacist before combining them.
When should you avoid Motilium?
It should be avoided if there is moderate or severe liver disease, a heart condition such as QT prolongation or heart failure, or significant potassium or magnesium imbalances. It is also avoided if there is gastrointestinal bleeding, intestinal obstruction or perforation, or a prolactinoma.
In practice, it's also advisable to avoid it if you're taking medications that can affect your heart rhythm or certain treatments that change how domperidone is metabolized.
During pregnancy, its use is reserved for when the doctor considers that the expected benefit justifies it. During breastfeeding, small amounts may pass into breast milk, and its use is recommended only if the doctor deems it clearly necessary.
What adverse effects are common and which are warning signs?
The package insert lists dry mouth as a common side effect. Others, such as headache or drowsiness, are listed as uncommon. If you experience palpitations or an irregular heartbeat, difficulty breathing, or fainting or loss of consciousness, stop taking the medication and seek medical attention.
Important: This text is for informational purposes only and does not replace medical advice. Always consult the official package insert and follow your doctor's or pharmacist's instructions for the exact dosage and use.
